What role does MTHFR play in Wechseljahre?

MTHFR encodes methylenetetrahydrofolate reductase, a key enzyme in folate and homocysteine metabolism. During menopause, declining estrogen levels can affect homocysteine – a risk factor for cardiovascular disease and possibly osteoporosis. Certain MTHFR variants (e.g., C677T) reduce enzyme activity and, combined with low folate or B12, may raise homocysteine. However, evidence is moderate: many studies show associations, but no causal, clinically actionable prediction for individual menopause trajectory. A DNA test alone is insufficient; measuring blood homocysteine, folate, and B12 is more informative. Adequate B-vitamin intake (diet or supplements) may help, but should be discussed with a physician. Menopause is multifactorial; MTHFR is only one small piece.