What role does CRP Entzündung play in skin aging?

CRP (C-reactive protein) is a systemic inflammatory marker produced in the liver in response to interleukin-6. Chronically elevated CRP levels (≥2 mg/L) are linked to 'inflammaging' – a low-grade, age-related inflammation that can accelerate skin aging. Mechanistically, CRP promotes the release of matrix metalloproteinases (MMPs), which degrade collagen and elastin, and induces oxidative stress in fibroblasts. Epidemiological studies (e.g., NHANES) show an association between higher CRP and increased wrinkling as well as reduced skin elasticity, but the evidence is largely observational and not causal. The effect size is moderate; lifestyle factors (smoking, UV exposure, diet) have a stronger impact. Direct skin CRP measurements are not standardized, and commercial blood tests for 'skin aging' often overstate clinical relevance. Lowering CRP through anti-inflammatory diet or exercise may support skin health, but specific anti-aging recommendations based solely on CRP are not evidence-based. Caution against overinterpreting single tests.