Evidence check: Zöliakie Test in the context of Sport

A celiac test in the context of sports can be useful if an athlete experiences unexplained fatigue, performance decline, or digestive issues. However, diagnosis is not based solely on a DNA test: HLA-DQ2/DQ8 genotyping indicates genetic susceptibility (necessary but not sufficient). Confirmed diagnosis requires serology (tTG-IgA) and duodenal biopsy. A standalone genetic test without clinical follow-up is misleading. For athletes, undiagnosed celiac disease can impair recovery and performance, but the test alone does not replace medical evaluation. Evidence: human-moderate (HLA testing well-established but only as a rule-out). Beware of marketing that presents genetic risk as a diagnosis.