Evidence check: MC4R in the context of Müdigkeit

MC4R (melanocortin-4 receptor) is a key regulator of energy homeostasis and appetite. Variants are strongly linked to obesity (GWAS, human studies). A direct link to fatigue is not established. Fatigue may arise secondarily from obesity or metabolic issues, but MC4R alone is not a predictive marker for tiredness. Evidence is weak and based on indirect pathways. MyBody-X does not include MC4R in its standard panel. Conservative assessment: no robust evidence for fatigue.