What role does VKORC1 play in sleep?

VKORC1 is a key gene in the vitamin K cycle, regulating the activation of clotting factors and vitamin K-dependent proteins. A direct role in sleep is not well established in current evidence. Some indirect links exist: vitamin K may influence sleep via sphingolipid metabolism, inflammation, or calcium homeostasis in the brain, but these are largely mechanistic hypotheses. VKORC1 variants (e.g., rs9923231) are primarily studied for warfarin sensitivity, not sleep. The evidence for a sleep-specific function is weak and speculative. Consumer genetic tests reporting VKORC1 for sleep are not supported by robust human studies. Any interpretation should be cautious and consider that sleep is multifactorial, with genetics playing a minor role compared to lifestyle and environment.