What to watch with CYP2D6 and Langlebigkeit?

CYP2D6 is a key drug-metabolizing enzyme responsible for breaking down about 20–25% of common medications. In longevity research, it has no directly proven role. Most associations are indirect: variants can affect the efficacy and tolerability of drugs often used in older age (e.g., beta-blockers, antidepressants, opioids). Some studies suggest links to hormone metabolism (e.g., estrogen), but the evidence is mechanistic and insufficient for predictive lifespan claims. Consumer DNA tests often provide pharmacogenetic insights, not longevity scores. Caution: Do not self-medicate or change dosages without medical supervision. The evidence is best classified as 'mechanistic' or 'mixed', as no robust human studies directly link CYP2D6 to extended lifespan.