Can Selen help with Langlebigkeit?

Selenium is an essential trace element that functions as a cofactor for selenoproteins (e.g., glutathione peroxidases) involved in antioxidant defense and thyroid metabolism. Observational studies suggest that low selenium status is associated with increased all-cause mortality, particularly in older adults. However, randomized controlled trials (RCTs) of selenium supplementation have not demonstrated consistent longevity benefits in well-nourished populations. In regions with selenium deficiency (e.g., parts of China), supplementation may reduce cancer risk, but in replete individuals, additional intake provides no clear advantage and can be toxic at high doses (selenosis). Genetic variants in selenoprotein genes (e.g., GPX1, SEPP1) influence selenium metabolism, but direct-to-consumer DNA tests claiming to predict longevity from these markers lack clinical validation. Bottom line: selenium is necessary for health, but supplementing for longevity is not supported by current evidence. A balanced diet typically provides adequate selenium. Evidence: human-moderate (observational data, but no robust RCTs for lifespan extension).