Can MTHFR help with Langlebigkeit?

MTHFR gene variants (C677T, A1298C) affect the activity of methylenetetrahydrofolate reductase, an enzyme that regulates homocysteine levels. Elevated homocysteine is a risk factor for cardiovascular disease, cognitive decline, and premature aging—all factors that can influence lifespan. However, direct evidence that MTHFR testing or targeted supplementation extends longevity is weak. Observational studies link homocysteine to mortality, but randomized controlled trials are lacking. Supplementation with folic acid, vitamin B6, and B12 can lower homocysteine, but whether this increases life expectancy is unproven. Moreover, the effects of MTHFR variants are small and modulated by diet, lifestyle, and other genes. Consumer DNA tests often oversimplify these findings. Clinically, the benefit is unclear, and self-supplementation without measuring homocysteine is not advised. Evidence: human-moderate. Caveat: consult a physician before taking supplements.