What should I know about MTHFR Männer?

The MTHFR variant (especially C677T) affects the conversion of folic acid to its active form, 5-methyltetrahydrofolate. In men, it is often discussed in relation to elevated homocysteine levels, which may influence cardiovascular risk. However, the evidence is mixed: some studies show weak associations with hypertension or fertility issues, but effect sizes are small and insufficient for standalone clinical recommendations. Importantly, a genetic test alone does not justify high-dose supplementation with folic acid or methylfolate without prior homocysteine measurement. Most individuals with MTHFR variants have normal homocysteine levels. Moreover, high doses of unconjugated folic acid (e.g., >1 mg/day) may carry risks. For men planning a family, adequate folate status may support sperm quality, but data are not conclusive. Overall: MTHFR is a small piece of the puzzle, not a health determinant.