What to watch with Progesteron and Müdigkeit?

Progesterone is commonly used in hormone replacement therapy and fertility treatments. Fatigue is a well-known side effect, especially with oral administration or high doses. The mechanism involves progesterone's calming effect on the central nervous system and potential impact on sleep quality. Genetic variants in the progesterone receptor (PGR) or CYP2C19 metabolism might influence individual tolerance, but consumer DNA tests lack clinical validation for such predictions. If you experience persistent fatigue while on progesterone, consider discussing with your doctor: dose adjustment, switching to a different route (e.g., vaginal or transdermal), or checking for underlying conditions like thyroid dysfunction or anemia. Do not self-adjust medication based on a DNA test. Evidence for nutrigenetic guidance on progesterone is limited; most recommendations are based on general practice rather than robust clinical trials.