Evidence check: Folsäure in the context of stress

Folic acid (vitamin B9) is essential for one-carbon metabolism, DNA synthesis, homocysteine regulation, and the production of neurotransmitters such as serotonin and dopamine. Chronic stress can elevate homocysteine levels, which is linked to cardiovascular and mental health strain. Adequate folate status may theoretically support stress resilience by lowering homocysteine and supporting neurotransmitter synthesis. However, direct evidence that folic acid supplementation reduces stress in non-deficient individuals is weak. Most research focuses on depression rather than general stress. Furthermore, high-dose folic acid can mask vitamin B12 deficiency, a concern especially for older adults and vegans. A balanced diet rich in folate (leafy greens, legumes) typically meets requirements. Without a confirmed deficiency, supplementing folic acid for stress management is not evidence-based. The evidence is graded as 'mechanistic' – biologically plausible but lacking robust clinical support.