What to watch with CYP2D6 and Schlaf?

CYP2D6 is a key drug-metabolizing enzyme that breaks down many medications – including some that affect sleep (e.g., certain antidepressants, antipsychotics, or opioids). Genetic variants (poor, intermediate, extensive, ultrarapid metabolizer) can alter drug efficacy and side effects. However, a direct effect of CYP2D6 on natural sleep-wake regulation is not established. Most associations with sleep issues are indirect and medication-mediated. Without concurrent drug use, a CYP2D6 genetic test is not informative for sleep problems. Be cautious of overinterpretation: consumer tests often list many genes, but clinical relevance for sleep is low. For sleep disorders, medical evaluation should come first.