Evidence check: Stuhlprobe in the context of Stress

The idea of using a stool sample to assess stress is based on the gut-brain axis: the gut and its microbiome communicate with the brain via nerves, hormones, and immune messengers. Mechanistic studies show that chronic stress can alter gut microbiota composition (dysbiosis), and conversely, a disturbed gut flora can influence stress responses. However, evidence for the clinical utility of a stool sample for stress diagnostics is still weak. There are no standardized biomarkers that can directly derive a person's stress level from a stool sample. Most studies are preclinical or have small sample sizes. A stool test can provide hints about inflammatory markers or certain bacteria, but interpreting it solely as a 'stress test' is not evidence-based. MyBody-X offers a gut microbiome test that analyzes the composition of the intestinal flora. This can give general insights into gut health, but not specifically measure stress. For stress diagnostics, established methods like questionnaires or cortisol measurements are more appropriate. Conclusion: The idea is mechanistically plausible but not sufficiently clinically proven. Evidence: mechanistic/unclear.