How are Folsäure and skin aging related?

The relationship between folate (vitamin B9) and skin aging is not well established by robust human evidence. Mechanistically, folate is essential for DNA synthesis and repair, as well as methylation reactions that support cell turnover and tissue regeneration. A deficiency could theoretically impair skin renewal and increase oxidative stress, potentially accelerating skin aging. However, direct clinical trials showing that folate supplementation reduces wrinkles or improves skin elasticity are lacking. Most evidence comes from in vitro studies or indirect associations (e.g., folate status and general health). Moreover, excessive folic acid intake (especially the synthetic form) carries risks, such as masking vitamin B12 deficiency. For skin aging, proven interventions include sun protection, smoking cessation, and a diet rich in antioxidants and polyphenols. Direct-to-consumer DNA tests that link folate-related gene variants (e.g., MTHFR) to skin aging often overstate the clinical utility. In summary, while a biological link is plausible, current evidence does not support using folate specifically to combat skin aging. A balanced diet covering all B vitamins is more sensible.