Evidence check: VKORC1 in the context of Langlebigkeit

VKORC1 encodes the vitamin K epoxide reductase, crucial for recycling vitamin K, which activates proteins involved in blood coagulation and vascular calcification. In longevity research, VKORC1 is indirectly relevant: adequate vitamin K status supports arterial elasticity and bone health, both linked to healthy aging. However, the strongest evidence for VKORC1 variants comes from pharmacogenetics (warfarin sensitivity), not from lifespan studies. Common SNPs like rs9923231 and rs7294 alter enzyme activity and may modulate vitamin K requirements, but their impact on longevity is unclear and likely small. Observational studies suggest associations with cardiovascular calcification, but no direct GWAS or centenarian data confirm a role in extending lifespan. Therefore, a consumer DNA test for VKORC1 alone cannot predict longevity. Evidence grade: mechanistic/unclear. Caveat: Do not self-supplement high-dose vitamin K without medical guidance, especially if on anticoagulants.