Evidence check: Omega-3 Index in the context of menopause

The Omega-3 Index (percentage of EPA and DHA in red blood cell membranes) is a validated biomarker for cardiovascular risk and inflammation. During menopause, declining estrogen increases cardiovascular risk, so a favorable Omega-3 Index may be protective. Some studies suggest benefits for hot flashes, mood, and bone health, but evidence is moderate and inconsistent. Genetic variants in FADS1/2 (e.g., rs174546) can affect omega-3 conversion efficiency, potentially influencing index values. The test itself is a reliable biomarker, but genotyping alone does not replace direct measurement. Caveat: No strong evidence for a specific menopause indication; omega-3 supplementation should be discussed with a physician, especially if on anticoagulants.