Myths vs facts: MTHFR and Langlebigkeit

MTHFR variants (C677T, A1298C) affect folate metabolism and can elevate homocysteine, a risk factor for cardiovascular disease. However, their impact on longevity is indirect and modest. Many myths claim MTHFR variants cause numerous chronic diseases and require special supplements. In reality, studies show only weak associations; most carriers never develop issues. A balanced diet with adequate folate (e.g., from leafy greens) is usually sufficient. High-dose folic acid may even pose risks in certain variants. Longevity is far more influenced by lifestyle factors like exercise, diet, and not smoking. A DNA test alone does not provide a reliable prognosis. Blood homocysteine measurements are more informative. The evidence is moderate and based on observational studies, not RCTs for life extension.