Risks and limits of Sportgene Ernährung

Sport gene nutrition tests claim to tailor training and diet based on DNA variants (e.g., ACTN3, ACE, COMT). However, the evidence is weak: most associations come from small GWAS with tiny effect sizes (e.g., COMT rs4680: p=6e-11, beta=0.07 per copy), which are not clinically predictive. Many tests lack independent validation and fall under marketing rather than evidence-based medicine. Such tests cannot diagnose medical conditions, reliably predict nutrient needs, or injury risk. Risks include misinterpretation, unnecessary supplement spending, or unsafe training adjustments (e.g., undetected cardiovascular issues). Tests are not validated for children or adolescents. Conclusion: scientific utility is limited; professional sports medicine or nutrition counseling is strongly recommended.