Myths vs facts: BDNF and Wechseljahre

BDNF (Brain-Derived Neurotrophic Factor) is a key protein for neuronal plasticity, memory, and mood. During menopause, estrogen levels drop, which can reduce BDNF expression – a potential factor in cognitive changes and depressive symptoms. Myth: BDNF supplements or specific genetic tests (e.g., BDNF Val66Met) offer a simple fix. Fact: Evidence is mostly mechanistic and from human studies of moderate strength. Exercise (especially endurance and resistance training) reliably increases BDNF, as does a Mediterranean diet rich in omega-3s and polyphenols. Direct BDNF supplements are not established; oral protein bioavailability is questionable. A DNA test for BDNF variants may hint at reduced activity, but effect sizes are small and clinical relevance unclear. Safety note: Do not self-medicate with high-dose supplements without medical supervision. Menopause is multifactorial; BDNF is only one piece.