What to watch with CYP1A2 and allergy?

The link between CYP1A2 variants and allergies is scientifically weak. CYP1A2 primarily metabolizes caffeine and some drugs. A few observational studies suggest a possible association with allergic conditions (e.g., hay fever), but results are inconsistent and not replicated. DTC tests often overclaim clinical relevance. There is no established recommendation to adjust diet or medication based solely on CYP1A2 genotype to influence allergies. Focus on proven allergen avoidance and symptomatic treatment. Evidence: human-observational (weak).