Lay opinion vs evidence: CRP Männer

CRP (C‑reactive protein) is a non‑specific inflammation marker. Lay opinion: 'High CRP = dangerous, low CRP = healthy.' Evidence is more nuanced. In men, reference ranges are slightly lower than in women (e.g., <1.0 mg/L vs. <3.0 mg/L), but a single value is rarely diagnostic. Chronically mildly elevated CRP (1–3 mg/L) may indicate subclinical inflammation linked to cardiovascular risk – evidence is moderate (prospective cohorts, no RCTs). Acute spikes (>10 mg/L) are usually due to infection or injury. Importantly, CRP is not a 'male‑specific' marker; its utility in primary prevention is limited. The American Heart Association recommends CRP testing only in intermediate‑risk individuals. Caveat: lifestyle factors (smoking, obesity) affect CRP more than genetics. A genetic test for CRP variants (e.g., rs1205) has no clinical consequence. Bottom line: evidence is moderate; avoid overinterpreting single values.