Evidence check: Hormoncheck Männer in the context of Langlebigkeit

A hormone check for men in the context of longevity is a popular but scientifically nuanced offering. While hormones like testosterone, DHEA, and cortisol are linked to aging processes, the evidence for routine hormone testing to optimize longevity is limited. The provided context shows that even for the stress hormone cortisol (NR3C1 gene), genetic testing cannot reliably diagnose high cortisol levels – blood or saliva tests are required. For thyroid hormones and selenium (GPX1), there are mechanistic hints but no strong evidence for DNA-based supplementation. A pure DNA hormone check often overstates clinical relevance. For longevity, lifestyle factors (diet, exercise, sleep, stress management) are far better supported than isolated hormone tests. Caveat: hormone replacement therapy should only be done under medical supervision due to risks (e.g., cardiovascular, prostate cancer). The evidence is mixed: there are human observational studies but no randomized long-term trials clearly demonstrating lifespan extension.