CRP (C-reactive protein) is a marker of inflammation measured in blood. Chronically elevated CRP is associated with higher risk of cardiovascular disease, diabetes, and accelerated aging. The question 'Can CRP inflammation help with longevity?' is misleading: inflammation itself is a risk factor, not a protective factor. Some studies suggest that lowering CRP through lifestyle changes (exercise, Mediterranean diet, weight loss) may improve healthspan, but direct evidence for extending maximum lifespan is lacking. Genetic variants affecting CRP (e.g., in the CRP gene) have small effects and are not clinically actionable. There is no evidence that artificially lowering CRP (e.g., via drugs) in healthy individuals promotes longevity – CRP also plays important immune roles. Thus, CRP is useful as a biomarker of inflammatory status, but not a direct target for longevity interventions. Be cautious of exaggerated claims from supplements that purport to lower CRP. Evidence: human-observational.
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