Is COMT useful for sleep?

Whether COMT is useful for sleep is a nuanced question. The COMT gene encodes an enzyme that degrades catecholamines like dopamine and norepinephrine. The common Val158Met polymorphism (rs4680) alters enzyme activity: Val carriers have higher activity (lower dopamine), Met carriers lower activity (higher dopamine). Some research suggests Met carriers may have better sleep quality and lower insomnia risk, while Val carriers might be more vulnerable to sleep disruption under stress. However, effect sizes are small, findings are inconsistent across populations, and many studies fail to replicate. Consumer genetic tests often overstate the clinical utility. There is no evidence that knowing your COMT status leads to improved sleep outcomes through targeted interventions. The evidence is mixed and insufficient for clinical recommendations. Good sleep hygiene remains the most evidence-based approach. Safety note: Do not use COMT results to self-medicate with supplements or medications without professional guidance.