Common mistakes around MTHFR Test

The MTHFR test is a common DNA test that is often misunderstood. The most frequent mistake is assuming that a variant (e.g., C677T) automatically causes serious health problems. In reality, many people carry this variant without any symptoms. Evidence shows that MTHFR variants can influence homocysteine levels, but the link to conditions like depression or thrombosis is complex and not causal. Another mistake is the uncritical use of methylfolate or methylcobalamin supplements without medical supervision. High doses can have side effects. Additionally, it is often overlooked that the test only covers a small part of folate metabolism. The clinical relevance for the general population is debated. Safety note: Do not change your medication without consulting a doctor. The test should be part of a comprehensive assessment, not a standalone decision tool.