What role does Helicobacter play in Allergie?

The rs4988235 variant is located near the LCT gene, which encodes lactase. The G allele is strongly associated with lactase non-persistence (primary lactose intolerance) in European populations. However, carrying this allele does not guarantee lactose intolerance; many carriers tolerate dairy due to other genetic, dietary, or microbial factors. The evidence comes from GWAS studies showing a statistical link, but the predictive value is limited. A DNA test alone is not diagnostic. If you experience symptoms like bloating, diarrhea, or cramps after consuming dairy, a clinical lactose tolerance test or hydrogen breath test is recommended. Additionally, factors such as gut microbiome composition, habitual dairy intake, and ancestry influence tolerance. The G allele is a risk indicator, not a definitive diagnosis.