Myths vs facts: MTHFR and Müdigkeit

MTHFR is a gene involved in folate metabolism. Variants like C677T and A1298C can reduce enzyme activity, potentially raising homocysteine levels. Some studies suggest a link between MTHFR polymorphisms and fatigue, especially in individuals with low folate status. However, the evidence is weak: effect sizes are small, and fatigue is multifactorial (sleep, stress, diet, other genes). Many commercial tests overstate MTHFR's role in 'detox' or 'energy'. Fact: lowering homocysteine with B-vitamins may help some, but robust clinical trials showing fatigue reduction are lacking. MyBody-X tests include MTHFR, but interpretation should be cautious. For persistent fatigue, medical workup (homocysteine, vitamin levels, thyroid) is more important than genetic testing.