Weight loss injections (GLP-1 agonists like semaglutide) are often portrayed as miracle cures. Evidence shows they can induce 10–15% weight loss in clinical trials, but the effect is highly dependent on concurrent dietary changes. Without a structured, protein-rich, high-fiber diet and exercise, results are suboptimal and weight regain is common after discontinuation. Side effects include nausea, gallstones, and muscle loss. Lay opinions frequently overestimate sustainability and underestimate the need for nutritional adaptation. The injection is not a substitute for lifestyle changes but a tool – and it is prescription-only for obesity or diabetes. Evidence: strong for short-term weight loss, moderate for long-term maintenance without diet.
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