Is Zöliakie Test useful for fatigue?

A celiac disease test (e.g., tTG-IgA, EMA, HLA-DQ2/DQ8) can be useful for fatigue if there are additional signs of celiac disease – such as chronic diarrhea, bloating, weight loss, or iron deficiency. Fatigue is a common but non-specific symptom of celiac disease. Without other indicators, general screening for celiac disease in isolated fatigue is not medically indicated because the pre-test probability is low. Direct-to-consumer tests (e.g., genetic risk tests for HLA variants) only provide risk estimation, not a diagnosis. A positive genetic test does not necessarily mean active celiac disease. The evidence for using a celiac test for fatigue alone is moderate: the diagnostic workup is validated when celiac is suspected (human-strong), but as a fatigue screening tool it is not supported. Seek medical advice before testing.