What to watch with Cardio Risk Check and fatigue?

If your MyBody-X Cardio Risk Check shows elevated risk and you are experiencing fatigue, several points deserve careful attention. The Cardio Risk Check is a polygenic risk score with limited individual predictive power – it explains only a small fraction of total risk and is ancestry-dependent. Fatigue has many possible causes: poor sleep, stress, thyroid dysfunction, iron deficiency, or vitamin B12 deficiency. If your DNA test includes a FUT2 variant (rs602661), B12 absorption may be slightly reduced; a blood test for holotranscobalamin or total B12 is advisable before supplementing. Another key consideration: Are you taking statins? The SLCO1B1 variant (rs4149056) increases the risk of statin-induced myopathy (muscle pain/fatigue). Evidence for this is strong (CPIC guideline). However, most carriers tolerate statins well. Do not stop any medication without consulting your doctor. A clinical workup is essential to identify the true cause of fatigue – a DNA test alone is not diagnostic.