How are CRP Entzündung and Langlebigkeit related?

C-reactive protein (CRP) is a key inflammatory marker produced in the liver in response to interleukin-6 (IL-6). Chronically mildly elevated CRP levels (0.3–3 mg/L) are linked to the concept of 'inflammaging' – age-related sterile low-grade inflammation that contributes to cellular senescence and age-associated diseases such as cardiovascular disease, type 2 diabetes, and cognitive decline. The genetic variant rs1800795 in the IL-6 gene (G allele) is associated in GWAS with slightly higher IL-6 and CRP levels, but the effect is small. Lifestyle factors (diet, exercise, sleep, smoking, stress) dominate inflammation regulation. A DNA test alone cannot predict lifespan; it only provides hints about a possible genetic predisposition. The evidence for a direct causal link between CRP and longevity is moderate – CRP is more a risk marker than a cause. Clinically, CRP should be interpreted within the overall inflammatory profile. Caveat: acute infections or injuries strongly elevate CRP and confound interpretation. For longevity assessment, additional biomarkers (e.g., HbA1c, lipids, telomere length) and a comprehensive history are needed.