How are VKORC1 and Sport related?

The relationship between VKORC1 and sport is indirect and centers on the gene's role in vitamin K metabolism. VKORC1 encodes an enzyme that recycles vitamin K, a cofactor for blood clotting and bone mineralization. In a sports context, variants in this gene could theoretically affect vitamin K availability, potentially influencing bone health (fracture risk) or clotting after injury. However, the evidence is weak: no robust studies directly link VKORC1 polymorphisms to athletic performance. Most data come from pharmacogenetics (e.g., warfarin dosing). For recreational or elite athletes, testing VKORC1 is not clinically actionable. A diet rich in vitamin K (kale, spinach) is more impactful for bone health than genetic testing. Evidence: mechanistic, based on biochemical pathways, not sports studies.