Evidence check: ACTN3 in the context of allergy

ACTN3 encodes alpha-actinin-3, a protein expressed in fast-twitch muscle fibers, and is well-established for its influence on sprint and power performance. In the context of allergy, however, the evidence is very limited. Some studies have explored links to asthma or bronchial hyperresponsiveness, but findings are inconsistent and not replicated. The proposed mechanisms (e.g., via muscle-derived inflammation or immune modulation) remain speculative. No clinical guideline recommends ACTN3 testing for allergy diagnosis or management. Consumer DNA tests that include ACTN3 in an allergy context are not supported by robust evidence. Conclusion: No clinically relevant role in allergy.