How are FTO and skin aging related?

The relationship between FTO and skin aging is not well established in the scientific literature. FTO (fat mass and obesity-associated gene) is primarily linked to body mass index (BMI) and obesity risk. Some studies suggest that FTO variants might indirectly affect skin aging through obesity-related pathways, inflammation, or oxidative stress. However, direct, reproducible associations between specific FTO SNPs (e.g., rs9939609) and skin aging markers like wrinkles or elasticity are lacking. The evidence is best described as mechanistic or unclear. Consumer DNA tests like MyBody-X may overstate such links. The most effective strategies for skin health remain a balanced diet, sun protection, adequate hydration, and a healthy lifestyle—regardless of FTO genotype.