How are Transferrin and Langlebigkeit related?

Transferrin is the primary iron transport protein in blood and a key regulator of iron homeostasis. Balanced iron levels are crucial for longevity because both deficiency and overload contribute to oxidative stress, inflammation, and age-related diseases such as cardiovascular disorders and neurodegeneration. Elevated transferrin saturation (e.g., in hereditary hemochromatosis) increases free iron, promoting oxidative damage and reducing lifespan. Low saturation indicates iron deficiency, which can impair energy metabolism, immunity, and cognition. Observational studies suggest a U-shaped relationship between transferrin saturation and mortality, with moderate levels being optimal. However, evidence is moderate and largely associative; genetic variants (e.g., HFE) modulate individual risk. Transferrin alone is not a standalone longevity marker—it must be interpreted alongside ferritin, hemoglobin, and clinical context. Safety note: Do not self-supplement iron without lab confirmation, as excess iron is pro-oxidant and potentially harmful.