Myths vs facts: SHBG and menopause

The question about myths vs facts regarding SHBG (sex hormone-binding globulin) and menopause is not directly addressed in the provided context. Generally, SHBG binds sex hormones and its levels often decline during menopause due to lower estrogen, potentially increasing free testosterone. However, the clinical relevance is complex and individual. Consumer DNA tests like MyBody-X do not measure SHBG directly and cannot diagnose menopausal hormone status. The evidence linking SHBG to menopausal symptoms is primarily mechanistic and observational, not from robust clinical trials. A common myth is that a single SHBG value explains hot flashes or mood changes—in reality, many factors are involved. Another myth is that saliva or urine SHBG tests are reliable—they are not. For hormone assessment, clinical blood tests (estradiol, FSH, SHBG) are required. Conclusion: SHBG is one piece of the puzzle, not a standalone menopause marker. Evidence is mechanistic/observational, insufficient for consumer-test-based recommendations.