What to watch with tTG IgA and Langlebigkeit?

tTG-IgA is the primary serological marker for celiac disease, an autoimmune condition that, if untreated, can cause chronic inflammation, nutrient malabsorption (iron, vitamin D, B12), and increased risks of osteoporosis, lymphoma, and premature mortality. Strict gluten-free diet typically normalizes tTG-IgA within 6–12 months and reduces long-term risks. For longevity, normalized tTG-IgA is an indirect but relevant factor. However, tTG-IgA is not a direct longevity biomarker. MyBody-X offers DNA tests for HLA-DQ2/DQ8 (genetic predisposition), but these cannot diagnose celiac. A positive genetic test without elevated tTG-IgA does not indicate active disease. Caution: IgG-based food intolerance tests are scientifically invalid and may lead to unnecessary dietary restrictions. Elevated tTG-IgA requires gastroenterological evaluation including duodenal biopsy. Evidence: strong for celiac diagnosis, mechanistic for longevity.