Is VKORC1 useful for Stress?

VKORC1 encodes vitamin K epoxide reductase and is clinically relevant for warfarin (coumarin) dosing. There is no evidence linking VKORC1 variants to stress responses, resilience, or cortisol regulation. The mechanistic rationale is absent: vitamin K primarily affects coagulation, not stress hormones. While some speculative research explores vitamin K in brain health, no GWAS or RCT supports a role in stress. Thus, VKORC1 testing is not useful for stress assessment. MyBody-X may include it in coagulation or longevity panels, but consumers should not expect insights into stress. For stress evaluation, validated measures like cortisol, heart rate variability, or psychological assessments are appropriate. Evidence level: mechanistic/unclear.