Lay opinion: Many believe that stress directly causes unhealthy eating and weight gain – e.g., cravings for sweets or fats. Evidence paints a more nuanced picture: Stress activates the HPA axis and raises cortisol, which can transiently increase appetite. However, individual responses vary greatly due to genetic factors (e.g., NR3C1 variants modulating cortisol sensitivity) and the gut microbiome. The effect size is moderate and not deterministic. DNA tests claiming to personalize stress-nutrition strategies currently lack sufficient clinical validity. Instead, sleep hygiene, exercise, and a balanced diet are proven to be more effective. The lay opinion oversimplifies a complex interplay of hormones, genes, and environment.
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