Insulin is primarily a hormone for blood glucose regulation and is not used as a skin care or anti-aging agent. Limited mechanistic evidence suggests topical insulin may aid wound healing (e.g., in diabetic ulcers), but there are no robust human studies for healthy skin or cosmetic purposes. When used systemically (e.g., in diabetes), insulin can actually cause skin issues such as lipodystrophy or acneiform eruptions. The idea of using insulin directly to improve skin lacks clinical evidence and carries risks like hypoglycemia or local irritation. MyBody-X DNA tests for insulin sensitivity or skin glycation are not clinically validated and rely on weak associations. Instead, proven measures like sun protection, moisturizing, and a low-glycemic diet are more relevant for skin health. Evidence grade: mechanistic/unclear.
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