Magnesium is often promoted as an anti-stress mineral, and there is some evidence that it can modestly lower cortisol levels. However, this does not directly translate into an anti-allergy effect. Allergic reactions are primarily driven by histamine and inflammatory mediators. Magnesium may theoretically influence histamine release from mast cells, but clinical evidence is weak. A few small studies suggest mild improvements in allergic rhinitis or itching, but results are inconsistent and not comparable to antihistamines. Importantly, correcting a magnesium deficiency is beneficial for overall health, but using magnesium as a standalone allergy treatment is not supported by evidence. For severe allergies (e.g., anaphylaxis), magnesium is not appropriate. If you consider magnesium supplementation alongside your doctor-prescribed allergy therapy, keep the dose below 350 mg/day from supplements and monitor kidney function. MyBody-X tests on magnesium and cortisol provide useful background but do not replace professional allergy diagnosis. Evidence level: mostly mechanistic, lacking robust human trials.
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