CRP (C-reactive protein) is a non-specific marker of systemic inflammation. In allergies, the immune response is typically localized and IgE-mediated, so CRP is often not elevated unless there is a secondary infection or chronic inflammatory condition like asthma. Evidence linking CRP directly to allergies is weak and inconsistent. CRP is more useful for monitoring bacterial infections or autoimmune diseases. For allergy assessment, specific markers such as IgE, eosinophil count, or skin-prick tests are more appropriate. If CRP is elevated in the context of allergies, consider other causes (infection, obesity, smoking). Caveat: CRP alone cannot diagnose or rule out allergies. Evidence level: mixed/unclear. Safety note: persistent high CRP warrants medical evaluation.
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