What role does CYP2D6 play in skin aging?

CYP2D6 is primarily known for metabolizing drugs, not for a direct role in skin aging. Some research suggests it may contribute to the metabolism of endogenous compounds like melatonin and estrogens, which could theoretically influence skin aging processes. However, the evidence is weak, inconsistent, and largely mechanistic. Direct-to-consumer DNA tests often overstate the link. Skin aging is driven by UV exposure, lifestyle, nutrition, and many other genetic factors. Do not change your diet or skincare based solely on a CYP2D6 result. Evidence grade: unclear/mechanistic.