What should I know about l glutamin leaky gut?

L-glutamine is often marketed for 'leaky gut' (increased intestinal permeability). Mechanistically, glutamine is a key fuel for enterocytes and may support gut barrier integrity. However, clinical evidence is limited: small studies show mixed results, and 'leaky gut' as a clinical entity remains controversial in mainstream medicine. Supplementation alone, without addressing underlying causes (diet, stress, medications), is not proven as a treatment. High doses (>30 g/day) may cause GI upset or other side effects. Caution in liver or kidney disease. Consult a healthcare professional before use. Evidence: mechanistic, no robust human trials.