What to watch with SHBG and Wechseljahre?

SHBG (sex hormone-binding globulin) is a key regulator of free sex hormones. During menopause, estrogen declines, often lowering SHBG, which can increase free testosterone relative to total levels. This shift may influence symptoms like energy, mood, and body composition. However, SHBG is also affected by insulin, liver function, and thyroid hormones. The provided context lacks direct studies on SHBG and menopause; it covers DNA variants in DRD2, ADIPOQ, FUT2, APOA5, BDNF, and general microbiome information. No specific SHBG-related data are present. Therefore, the evidence is purely mechanistic: we can explain the physiology, but no personalized conclusions can be drawn from the given data. Consumer DNA tests reporting SHBG-related SNPs (e.g., in the SHBG gene) often lack clinical validation. Important: Menopausal symptoms warrant medical evaluation including hormone panels (free estradiol, testosterone, SHBG). DNA-based wellness tests are not diagnostic tools.