Myths vs facts: CRP Entzündung and longevity

Myth: High CRP (C-reactive protein) directly causes aging, and lowering it guarantees a longer life. Fact: CRP is a well-established but non-specific marker of systemic inflammation. Large epidemiological studies (e.g., Whitehall II, NHANES) consistently link elevated CRP to increased cardiovascular risk and all-cause mortality. However, CRP is not causal – it reflects underlying inflammatory processes driven by lifestyle, obesity, smoking, or infections. Lowering CRP alone (e.g., with statins) does not necessarily improve longevity if root causes remain. Genetic variants in the CRP gene have only small effects on CRP levels and are not significantly associated with lifespan extension. The evidence is moderate: the association is robust, but causality is unclear. To promote longevity, focus on anti-inflammatory diet, regular exercise, weight management, and stress reduction – not on chasing a single lab value. Single CRP measurements can be skewed by acute infections. Bottom line: CRP is a useful risk indicator, not a direct 'longevity switch'.