What to watch with Homocystein and Müdigkeit?

Homocysteine is a byproduct of methionine metabolism. Elevated levels can indicate deficiencies in vitamin B12, B6, or folate, and are associated with fatigue in some studies. However, the evidence for a causal link between high homocysteine and fatigue is moderate. Many individuals with elevated homocysteine are asymptomatic. DNA tests for MTHFR variants (e.g., C677T) are commonly marketed, but clinical utility is limited: lowering homocysteine via supplementation does not necessarily improve fatigue. Instead, consult a doctor to rule out actual deficiencies. Beware of overblown marketing claims. Evidence: human-moderate.