Evidence check: HLA-DQ2 in the context of fatigue

The provided knowledge context does not contain specific information on HLA-DQ2 and fatigue. HLA-DQ2 is a genetic risk factor for celiac disease, an autoimmune condition that can present with fatigue. However, the link is indirect: only a minority of HLA-DQ2 carriers develop celiac disease, and fatigue has numerous causes. The evidence for a direct HLA-DQ2–fatigue connection is therefore 'mixed' – mechanistic plausibility exists, but strong clinical evidence is lacking in this dataset. Consumer genetic tests often overstate the predictive value of HLA-DQ2. A positive result alone does not diagnose celiac disease or explain fatigue. Persistent fatigue warrants medical evaluation including history, serology (tTG-IgA), and possibly duodenal biopsy. The database offers no support for personalized recommendations based solely on HLA-DQ2.