Is tTG IgA useful for stress?

tTG IgA (tissue transglutaminase antibody) is a well-established biomarker for celiac disease, not for stress. There is no scientific evidence that tTG IgA levels are influenced by psychological or physiological stress, nor that it is useful for stress assessment. Confusion may arise because stress can exacerbate gut symptoms, but tTG IgA specifically measures the immune response to gluten. A positive result indicates celiac disease, not stress. For stress-related gut issues, other biomarkers like cortisol, α-amylase, or calprotectin are more relevant. Caveat: using tTG IgA without medical indication can lead to unnecessary anxiety. Evidence for its use in stress: none.