What to watch with COMT and longevity?

COMT (catechol-O-methyltransferase) degrades dopamine, norepinephrine, and estrogens. The common Val158Met (rs4680) variant alters enzyme activity: Met carriers have lower activity, leading to higher dopamine levels but potentially increased oxidative stress. Some research links COMT to cognitive aging, stress response, and possibly longevity, but effect sizes are small and depend on sex, diet, and other factors. The provided context does not include any specific COMT information. MyBody-X tests focus on nutrition and longevity markers, but it is unclear whether COMT is included. If it is, results should be interpreted as exploratory, not clinical. Evidence: unclear. Caveat: Do not change medications or supplements based solely on COMT genotype without professional guidance.